Description
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis.
Product information
CAS Number: 902779-59-3
Molecular Weight: 381.73
Formula: C11H9Cl2CuN3O2S
Chemical Name: copper(2+) {N-[(Z)-[(4-oxo-4H-chromen-3-yl)methylidene]amino]carbamimidoyl}sulfanide hydrochloride chloride
Smiles: [Cl-].Cl.[Cu+2].N=C([S-])N/N=C\C1=COC2=CC=CC=C2C1=O
InChiKey: HZRXQEVFXXQYFS-KHDHKOIVSA-L
InChi: InChI=1S/C11H9N3O2S.2ClH.Cu/c12-11(17)14-13-5-7-6-16-9-4-2-1-3-8(9)10(7)15;;;/h1-6H,(H3,12,14,17);2*1H;/q;;;+2/p-2/b13-5-;;;
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively.
In Vivo:
FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells.
Products are for research use only. Not for human use.
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