Description
SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.
Product information
CAS Number: 1064662-40-3
Molecular Weight: 550.18
Formula: C32H44ClN5O
Chemical Name: 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(pyrrolidin-1-yl)propyl]imidazo[1,2-a]pyridine-6-carboxamide hydrochloride
Smiles: Cl.CC(C)CCN(CCC(C)C)C(=O)C1=CN2C(C=C1)=NC(C1C=CC(=CC=1)C#N)=C2CCCN1CCCC1
InChiKey: FBNJDWPWZNPVSC-UHFFFAOYSA-N
InChi: InChI=1S/C32H43N5O.ClH/c1-24(2)15-20-36(21-16-25(3)4)32(38)28-13-14-30-34-31(27-11-9-26(22-33)10-12-27)29(37(30)23-28)8-7-19-35-17-5-6-18-35;/h9-14,23-25H,5-8,15-21H2,1-4H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 250 mg/mL (454.40 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5.
In Vivo:
Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss.
Products are for research use only. Not for human use.
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