RWJ-51204


Catalog No. Size PriceQuantity
M20076-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors.

Product information

CAS Number: 205701-85-5

Molecular Weight: 399.39

Formula: C21H19F2N3O3

Chemical Name: 8-(ethoxymethyl)-5-fluoro-N-(2-fluorophenyl)-11-oxo-1,8-diazatricyclo[7.4.0.0²,⁷]trideca-2,4,6,9-tetraene-10-carboxamide

Smiles: CCOCN1C2=C(C(=O)NC3=CC=CC=C3F)C(=O)CCN2C2=CC=C(F)C=C12

InChiKey: VQOQDABVGWLROX-UHFFFAOYSA-N

InChi: InChI=1S/C21H19F2N3O3/c1-2-29-12-26-17-11-13(22)7-8-16(17)25-10-9-18(27)19(21(25)26)20(28)24-15-6-4-3-5-14(15)23/h3-8,11H,2,9-10,12H2,1H3,(H,24,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RWJ-51204 binds to receptors in the cerebral cortex, cerebellum, or medulla-spinal cord with Ki ranging from 0.2 to 0.6 nM.

In Vivo:

RWJ-51204 is orally active in anxiolytic efficacy tests. WJ 51204 dose-relatedly antagonizes PTZ-induced clonic convulsions when administered orally (ED50 = 0.04 mg/kg). RWJ-51204 is effective in the conflict test in monkeys (ED50 of approximately 0.5 mg/kg p.o.). RWJ-51204 potently impairs rotarod performance in rats (ED50 = 0.12 mg/kg), and all rats given RWJ-51204 orally at 30 mg/kg exhibit sedation, reduced skeletal muscle tone, and impairment of rotarod performance.

Products are for research use only. Not for human use.

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