ASP2535


Catalog No. Size PriceQuantity
M20107-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.

Product information

CAS Number: 374886-51-8

Molecular Weight: 382.42

Formula: C22H18N6O

Chemical Name: 4-[3-(6-phenylpyridin-3-yl)-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole

Smiles: CC(C)C1=NN=C(C2C=NC(=CC=2)C2C=CC=CC=2)N1C1=CC=CC2=NON=C21

InChiKey: FQGLDGKVKDPVLO-UHFFFAOYSA-N

InChi: InChI=1S/C22H18N6O/c1-14(2)21-24-25-22(28(21)19-10-6-9-18-20(19)27-29-26-18)16-11-12-17(23-13-16)15-7-4-3-5-8-15/h3-14H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro.

In Vivo:

ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice. ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats.

Products are for research use only. Not for human use.

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