L-689560


Catalog No. Size PriceQuantity
M20117-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.

Product information

CAS Number: 139051-78-8

Molecular Weight: 380.23

Formula: C17H15Cl2N3O3

Chemical Name: (2S,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

Smiles: OC(=O)[C@@H]1C[C@H](NC(=O)NC2C=CC=CC=2)C2C(=CC(Cl)=CC=2Cl)N1

InChiKey: UCKHICKHGAOGAP-KBPBESRZSA-N

InChi: InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

L-689560 is a 2-carboxytetrahydroquinoline antagonist.

In Vivo:

L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model

Products are for research use only. Not for human use.

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