LAS-31180


Catalog No. Size PriceQuantity
M20272-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

Product information

CAS Number: 137338-43-3

Molecular Weight: 252.29

Formula: C11H12N2O3S

Chemical Name: N-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)methanesulfonamide

Smiles: CN1C=C(NS(C)(=O)=O)C(=O)C2C=CC=CC1=2

InChiKey: LSIYNVMXGMDGMG-UHFFFAOYSA-N

InChi: InChI=1S/C11H12N2O3S/c1-13-7-9(12-17(2,15)16)11(14)8-5-3-4-6-10(8)13/h3-7,12H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts.

In Vivo:

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure.

Products are for research use only. Not for human use.

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