Description
RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT.
Product information
CAS Number: 136609-26-2
Molecular Weight: 416.58
Formula: C25H28N4S
Chemical Name: 2-{[5-(3,5-dimethyl-1H-pyrazol-1-yl)pentyl]sulfanyl}-4,5-diphenyl-1H-imidazole
Smiles: CC1C=C(C)N(CCCCCSC2NC(=C(N=2)C2C=CC=CC=2)C2C=CC=CC=2)N=1
InChiKey: UUPITLNVYVCTFW-UHFFFAOYSA-N
InChi: InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM.
In Vivo:
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.
Products are for research use only. Not for human use.
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