SB-203186 hydrochloride


Catalog No. Size PriceQuantity
M20327-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SB-203186 hydrochloride is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively.

Product information

CAS Number: 207572-69-8

Molecular Weight: 308.80

Formula: C16H21ClN2O2

Chemical Name: 2-(piperidin-1-yl)ethyl 1H-indole-3-carboxylate hydrochloride

Smiles: Cl.O=C(OCCN1CCCCC1)C1=CNC2=CC=CC=C12

InChiKey: LYMBEMCUJNDSBZ-UHFFFAOYSA-N

InChi: InChI=1S/C16H20N2O2.ClH/c19-16(20-11-10-18-8-4-1-5-9-18)14-12-17-15-7-3-2-6-13(14)15;/h2-3,6-7,12,17H,1,4-5,8-11H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (323.83 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Pretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips.

In Vivo:

Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg. SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency.

Products are for research use only. Not for human use.

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