Ca2+ channel agonist 1


Catalog No. Size PriceQuantity
M20531-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

Product information

CAS Number: 1402821-24-2

Molecular Weight: 354.45

Formula: C19H26N6O

Chemical Name: (2R)-2-{[6-(benzylamino)-9-propyl-9H-purin-2-yl]amino}butan-1-ol

Smiles: CC[C@H](CO)NC1N=C2C(N=CN2CCC)=C(NCC2C=CC=CC=2)N=1

InChiKey: LKXPLOHGQSEPEM-OAHLLOKOSA-N

InChi: InChI=1S/C19H26N6O/c1-3-10-25-13-21-16-17(20-11-14-8-6-5-7-9-14)23-19(24-18(16)25)22-15(4-2)12-26/h5-9,13,15,26H,3-4,10-12H2,1-2H3,(H2,20,22,23,24)/t15-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (141.06 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Ca2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Products are for research use only. Not for human use.

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