Description
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy.
Product information
CAS Number: 1243245-18-2
Molecular Weight: 448.49
Formula: C24H25FN6O2
Chemical Name: N-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]-2-{2'-fluoro-3-methyl-[2,4'-bipyridin]-5-yl}acetamide
Smiles: CC(=O)N1CCN(CC1)C1=CN=C(C=C1)NC(=O)CC1C=C(C)C(=NC=1)C1=CC(F)=NC=C1
InChiKey: AXXNRMISICMFNS-UHFFFAOYSA-N
InChi: InChI=1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(H,27,29,33)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 36 mg/mL (80.27 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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