EPZ020411 hydrochloride


Catalog No. Size PriceQuantity
M20556-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.

Product information

CAS Number: 2070015-25-5

Molecular Weight: 479.06

Formula: C25H39ClN4O3

Chemical Name: methyl[2-(methylamino)ethyl][(3-{4-[(1r,3r)-3-[2-(oxan-4-yl)ethoxy]cyclobutoxy]phenyl}-1H-pyrazol-4-yl)methyl]amine hydrochloride

Smiles: Cl.CNCCN(C)CC1=CNN=C1C1C=CC(=CC=1)O[C@@H]1C[C@H](C1)OCCC1CCOCC1

InChiKey: LIDZHJMYAKPGOJ-FBGQUBCLSA-N

InChi: InChI=1S/C25H38N4O3.ClH/c1-26-10-11-29(2)18-21-17-27-28-25(21)20-3-5-22(6-4-20)32-24-15-23(16-24)31-14-9-19-7-12-30-13-8-19;/h3-6,17,19,23-24,26H,7-16,18H2,1-2H3,(H,27,28);1H/t23-,24-;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (104.37 mM; Need ultrasonic). H2O : ≥ 41 mg/mL (85.58 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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