IPI-3063


Catalog No. Size PriceQuantity
M20589-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

IPI-3063 is a potent and selective PI3K p110δ inhibitor with an IC50 of 2.5 ± 1.2 nM.

Product information

CAS Number: 1425043-73-7

Molecular Weight: 455.51

Formula: C25H25N7O2

Chemical Name: 4-amino-6-{[(1S)-1-[8-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1-oxo-2-(propan-2-yl)-1,2-dihydroisoquinolin-3-yl]ethyl]amino}pyrimidine-5-carbonitrile

Smiles: CN1C=C(C=CC1=O)C1=CC=CC2C=C([C@H](C)NC3N=CN=C(N)C=3C#N)N(C(C)C)C(=O)C=21

InChiKey: OBHAYOJCPNWKBL-HNNXBMFYSA-N

InChi: InChI=1S/C25H25N7O2/c1-14(2)32-20(15(3)30-24-19(11-26)23(27)28-13-29-24)10-16-6-5-7-18(22(16)25(32)34)17-8-9-21(33)31(4)12-17/h5-10,12-15H,1-4H3,(H3,27,28,29,30)/t15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 83.33 mg/mL (182.94 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

IPI-3063 inhibits p110α, p110β, and p110γ with IC50s of 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1. IPI-3063 is a p110δ selective compound with an IC50=0.1 nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very potent in reducing p-AKT (significant effect at 1 nM). IPI-3063 also reduces p-ERK1/2 with a significant effect at 10 nM. IPI-3063 is very potent, achieving a significant decrease in B cell survival when present at 10 nM.

Products are for research use only. Not for human use.

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