Description
AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell.
Product information
CAS Number: 2089288-03-7
Molecular Weight: 477.57
Formula: C27H32FN5O2
Chemical Name: 7-fluoro-3-methyl-8-{6-[3-(piperidin-1-yl)propoxy]pyridin-3-yl}-1-(propan-2-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-2-one
Smiles: CN1C(=O)N(C(C)C)C2C1=CN=C1C=C(F)C(=CC1=2)C1=CN=C(C=C1)OCCCN1CCCCC1
InChiKey: VQSZIPCGAGVRRP-UHFFFAOYSA-N
InChi: InChI=1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (52.35 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390.
Products are for research use only. Not for human use.
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