Description
SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.
Product information
CAS Number: 181629-93-6
Molecular Weight: 431.38
Formula: C22H17F4N3O2
Chemical Name: N-[3-fluoro-5-(pyridin-3-yl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydro-1H-indole-1-carboxamide
Smiles: COC1=CC2CCN(C(=O)NC3=CC(F)=CC(=C3)C3C=NC=CC=3)C=2C=C1C(F)(F)F
InChiKey: RRJLJKRFFRZRAF-UHFFFAOYSA-N
InChi: InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy.
Products are for research use only. Not for human use.
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