L-371, 257


Catalog No. Size PriceQuantity
M20725-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).

Product information

CAS Number: 162042-44-6

Molecular Weight: 507.58

Formula: C28H33N3O6

Chemical Name: 1-(1-{4-[(1-acetylpiperidin-4-yl)oxy]-2-methoxybenzoyl}piperidin-4-yl)-2,4-dihydro-1H-3,1-benzoxazin-2-one

Smiles: CC(=O)N1CCC(CC1)OC1C=CC(=C(C=1)OC)C(=O)N1CCC(CC1)N1C2=CC=CC=C2COC1=O

InChiKey: WDERJSQJYIJOPD-UHFFFAOYSA-N

InChi: InChI=1S/C28H33N3O6/c1-19(32)29-15-11-22(12-16-29)37-23-7-8-24(26(17-23)35-2)27(33)30-13-9-21(10-14-30)31-25-6-4-3-5-20(25)18-36-28(31)34/h3-8,17,21-22H,9-16,18H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Systemic administration of nonpenetrant oxytocin receptor antagonist L-371,257 (0.5 and 1.0 mg/kg; i.p. injection) stimulates weight gain in rats.

Products are for research use only. Not for human use.

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