Bobcat339 hydrochloride


Catalog No. Size PriceQuantity
M20740-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.

Product information

CAS Number: 2436747-44-1

Molecular Weight: 334.20

Formula: C16H13Cl2N3O

Chemical Name: 4-amino-1-{[1,1'-biphenyl]-3-yl}-5-chloro-1,2-dihydropyrimidin-2-one hydrochloride

Smiles: Cl.NC1=NC(=O)N(C=C1Cl)C1C=C(C=CC=1)C1C=CC=CC=1

InChiKey: ZOMPKMMOPYMRIB-UHFFFAOYSA-N

InChi: InChI=1S/C16H12ClN3O.ClH/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11;/h1-10H,(H2,18,19,21);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 130 mg/mL (388.99 mM; Need ultrasonic). H2O : 0.1 mg/mL (0.30 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.

Products are for research use only. Not for human use.

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