Description
Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity.
Product information
CAS Number: 461000-66-8
Molecular Weight: 428.50
Formula: C22H24N2O5S
Chemical Name: 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Smiles: COCCN(C(=O)C1=CC(OC)=C(OC)C(=C1)OC)C1=NC(=CS1)C1C=CC=CC=1
InChiKey: ZUXNHFFVQWADJL-UHFFFAOYSA-N
InChi: InChI=1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (116.69 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC50 of 11.6 ± 2.5 μM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels.
Products are for research use only. Not for human use.
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