A-381393


Catalog No. Size PriceQuantity
M20762-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM).

Product information

CAS Number: 726174-00-1

Molecular Weight: 320.43

Formula: C20H24N4

Chemical Name: 2-{[4-(3,4-dimethylphenyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole

Smiles: CC1=CC(=CC=C1C)N1CCN(CC2NC3=CC=CC=C3N=2)CC1

InChiKey: SAQMCVDGOIRQTC-UHFFFAOYSA-N

InChi: InChI=1S/C20H24N4/c1-15-7-8-17(13-16(15)2)24-11-9-23(10-12-24)14-20-21-18-5-3-4-6-19(18)22-20/h3-8,13H,9-12,14H2,1-2H3,(H,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 51.67 mg/mL (161.25 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

A-381393 exhibits weak affinity at 5-HT1A, Sigma 2, Adenoceptor α1A, Adenoceptor α2C, Histamine H1, with Kis of 1365, 8600, 2044, 1912 and 2962 nM, respectively.

Products are for research use only. Not for human use.

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