NVP-DPP728 dihydrochloride


Catalog No. Size PriceQuantity
M20860-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.

Product information

CAS Number: 207556-62-5

Molecular Weight: 371.26

Formula: C15H20Cl2N6O

Chemical Name: 6-[(2-{[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino}ethyl)amino]pyridine-3-carbonitrile dihydrochloride

Smiles: Cl.Cl.N#CC1CCCN1C(=O)CNCCNC1C=CC(=CN=1)C#N

InChiKey: VNACOBVZDCLAEV-UHFFFAOYSA-N

InChi: InChI=1S/C15H18N6O.2ClH/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17;;/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20);2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.

In Vivo:

NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.

Products are for research use only. Not for human use.

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