(1S, 3R, 5R)-PIM447 dihydrochloride

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

Product information

CAS Number: 2096989-57-8

Molecular Weight: 513.38

Formula: C24H25Cl2F3N4O

Chemical Name: N-{4-[(1S,3R,5R)-3-amino-5-methylcyclohexyl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide dihydrochloride

Smiles: Cl.Cl.C[C@@H]1C[C@@H](C[C@H](N)C1)C1C=CN=CC=1NC(=O)C1C=CC(F)=C(N=1)C1C(F)=CC=CC=1F

InChiKey: BVRSHQQSBGCMJE-ISUJJMBGSA-N

InChi: InChI=1S/C24H23F3N4O.2ClH/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26;;/h2-8,12-15H,9-11,28H2,1H3,(H,31,32);2*1H/t13-,14+,15-;;/m1../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 33.33 mg/mL (64.92 mM; Need ultrasonic). H2O : 12.5 mg/mL (24.35 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.