EHNA hydrochloride


Catalog No. Size PriceQuantity
M21010-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

Product information

CAS Number: 58337-38-5

Molecular Weight: 313.83

Formula: C14H24ClN5O

Chemical Name: (2R,3S)-3-(6-amino-9H-purin-9-yl)nonan-2-ol hydrochloride

Smiles: Cl.C[C@@H](O)[C@H](CCCCCC)N1C=NC2=C(N)N=CN=C12

InChiKey: VVDXNJRUNJMYOZ-DHXVBOOMSA-N

InChi: InChI=1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 250 mg/mL (796.61 mM). H2O : 100 mg/mL (318.64 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity. EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity. EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.

Products are for research use only. Not for human use.

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