HQL-79


Catalog No. Size PriceQuantity
M21030-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS.

Product information

CAS Number: 162641-16-9

Molecular Weight: 377.48

Formula: C22H27N5O

Chemical Name: 4-(diphenylmethoxy)-1-[3-(2H-1,2,3,4-tetrazol-5-yl)propyl]piperidine

Smiles: C(CCN1CCC(CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1)C1N=NNN=1

InChiKey: TZQGXAHOROZEKN-UHFFFAOYSA-N

InChi: InChI=1S/C22H27N5O/c1-3-8-18(9-4-1)22(19-10-5-2-6-11-19)28-20-13-16-27(17-14-20)15-7-12-21-23-25-26-24-21/h1-6,8-11,20,22H,7,12-17H2,(H,23,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH.

Products are for research use only. Not for human use.

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