Description
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
Product information
CAS Number: 501-97-3
Molecular Weight: 166.17
Formula: C9H10O3
Chemical Name: 3-(4-hydroxyphenyl)propanoic acid
Smiles: OC1C=CC(CCC(O)=O)=CC=1
InChiKey: NMHMNPHRMNGLLB-UHFFFAOYSA-N
InChi: InChI=1S/C9H10O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5,10H,3,6H2,(H,11,12)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (601.76 mM; Need ultrasonic). H2O : 33.33 mg/mL (200.57 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice.
Products are for research use only. Not for human use.
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