RPR-260243


Catalog No. Size PriceQuantity
M21211-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC50=58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel.

Product information

CAS Number: 668463-35-2

Molecular Weight: 510.50

Formula: C28H25F3N2O4

Chemical Name: (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxopropyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-yn-1-yl]piperidine-3-carboxylic acid

Smiles: COC1C=C2C(=CC=NC2=CC=1)C(=O)CC[C@@H]1CCN(C[C@@H]1C(O)=O)CC#CC1=CC(F)=CC(F)=C1F

InChiKey: VWNMWKSURFWKAL-HXOBKFHXSA-N

InChi: InChI=1S/C28H25F3N2O4/c1-37-20-5-6-25-22(15-20)21(8-10-32-25)26(34)7-4-17-9-12-33(16-23(17)28(35)36)11-2-3-18-13-19(29)14-24(30)27(18)31/h5-6,8,10,13-15,17,23H,4,7,9,11-12,16H2,1H3,(H,35,36)/t17-,23+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 10 mg/mL (19.59 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RPR-260243 enhances the delayed rectifier current in guinea pig myocytes but, when administered alone, has little effect on action potential parameters in these cells.

Products are for research use only. Not for human use.

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