Description
PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.IC50 value: 44 nMTarget: sigma receptorin vitro: PRE-084 has an IC50 of more than 100,000 nM for PCP receptors and an IC50 higher than 10,000 nM in a variety of other receptor systems. in vivo: PRE-084 improves motor neuron survival and motor performance in wobbler mice. PRE-084 enhances BDNF-mediated trophic support.
Product information
CAS Number: 75136-54-8
Molecular Weight: 353.88
Formula: C19H28ClNO3
Chemical Name: 2-(morpholin-4-yl)ethyl 1-phenylcyclohexane-1-carboxylate hydrochloride
Smiles: Cl.O=C(OCCN1CCOCC1)C1(CCCCC1)C1C=CC=CC=1
InChiKey: QUJWFJNHTBKCLU-UHFFFAOYSA-N
InChi: InChI=1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 34 mg/mL (96.08 mM). H2O : 33.33 mg/mL (94.18 mM; ultrasonic and warming and heat to 60°C).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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