Description
SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death.
Product information
CAS Number: 2387704-62-1
Molecular Weight: 499.36
Formula: C21H20Cl2N10O
Chemical Name: N-[(5,6-dichloro-1H-1,3-benzodiazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(morpholin-4-yl)-9H-purin-6-amine
Smiles: CN1C=C(C=N1)N1C=NC2=C(NCC3NC4C=C(Cl)C(Cl)=CC=4N=3)N=C(N=C12)N1CCOCC1
InChiKey: FSELUFUYNUNZKD-UHFFFAOYSA-N
InChi: InChI=1S/C21H20Cl2N10O/c1-31-10-12(8-26-31)33-11-25-18-19(29-21(30-20(18)33)32-2-4-34-5-3-32)24-9-17-27-15-6-13(22)14(23)7-16(15)28-17/h6-8,10-11H,2-5,9H2,1H3,(H,27,28)(H,24,29,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60°C). H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SR-4835 (90 nM; 0.5-48 hours) suppresses ATM and RAD51 protein levels. SR-4835 inhibits CDK12/CDK13 which triggers intronic polyadenylation site cleavage and suppresses the expression of core DNA damage response proteins.
Products are for research use only. Not for human use.
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