Description
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.
Product information
CAS Number: 1384424-80-9
Molecular Weight: 362.31
Formula: C17H13F3N4O2
Chemical Name: (Z)-N'-(7-methoxyquinolin-4-yl)-N-[6-(trifluoromethyl)pyridin-2-yl]carbamimidic acid
Smiles: COC1=CC2=NC=CC(/N=C(\O)/NC3=CC=CC(=N3)C(F)(F)F)=C2C=C1
InChiKey: VQPBIJGXSXEOCU-UHFFFAOYSA-N
InChi: InChI=1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 83.33 mg/mL (230.00 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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