AMG 579


Catalog No. Size PriceQuantity
M21749-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.

Product information

CAS Number: 1227067-61-9

Molecular Weight: 441.48

Formula: C25H23N5O3

Chemical Name: 1-(4-{3-[4-(1H-1,3-benzodiazole-2-carbonyl)phenoxy]pyrazin-2-yl}piperidin-1-yl)ethan-1-one

Smiles: CC(=O)N1CCC(CC1)C1=NC=CN=C1OC1C=CC(=CC=1)C(=O)C1NC2=CC=CC=C2N=1

InChiKey: ZNPDAYJZIRPRFQ-UHFFFAOYSA-N

InChi: InChI=1S/C25H23N5O3/c1-16(31)30-14-10-17(11-15-30)22-25(27-13-12-26-22)33-19-8-6-18(7-9-19)23(32)24-28-20-4-2-3-5-21(20)29-24/h2-9,12-13,17H,10-11,14-15H2,1H3,(H,28,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 41.67 mg/mL (94.39 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

AMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%.

Products are for research use only. Not for human use.

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