DPP-IV-IN-1


Catalog No. Size PriceQuantity
M21773-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM.

Product information

CAS Number: 625110-37-4

Molecular Weight: 243.28

Formula: C11H18FN3O2

Chemical Name: (2S,4S)-4-fluoro-1-{2-[(1-hydroxy-2-methylpropan-2-yl)amino]acetyl}pyrrolidine-2-carbonitrile

Smiles: CC(C)(CO)NCC(=O)N1C[C@@H](F)C[C@H]1C#N

InChiKey: XJGUWEAPKPNAID-IUCAKERBSA-N

InChi: InChI=1S/C11H18FN3O2/c1-11(2,7-16)14-5-10(17)15-6-8(12)3-9(15)4-13/h8-9,14,16H,3,5-7H2,1-2H3/t8-,9-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

DPP-IV-IN-1 (0.1 and 0.3 mg/kg, p.o.) reduces the increase in plasma glucose beginning 30 min after glucose loading, and significantly suppresses hyperglycemia at the dose of 0.3 mg/kg in a rat model of obesity and impaired glucose tolerance. The effect is based on its inhibitory effect on plasma DPP-IV activity.

Products are for research use only. Not for human use.

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