Saredutant


Catalog No. Size PriceQuantity
M21798-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Saredutant is a selective NK2 receptor antagonist.

Product information

CAS Number: 142001-63-6

Molecular Weight: 552.53

Formula: C31H35Cl2N3O2

Chemical Name: N-[(2S)-2-(3,4-dichlorophenyl)-4-(4-acetamido-4-phenylpiperidin-1-yl)butyl]-N-methylbenzamide

Smiles: CN(C[C@@H](CCN1CCC(CC1)(NC(C)=O)C1C=CC=CC=1)C1=CC(Cl)=C(Cl)C=C1)C(=O)C1C=CC=CC=1

InChiKey: PGKXDIMONUAMFR-AREMUKBSSA-N

InChi: InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (452.46 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility.

Products are for research use only. Not for human use.

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