Description
Sigma-LIGAND-1 is a selective sigma receptor ligand, has receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP site, and a Ki of 4000 nM at the dopamine D2 receptor.
Product information
CAS Number: 139652-01-0
Molecular Weight: 435.56
Formula: C27H33NO4
Chemical Name: 6-{[6-(4-hydroxypiperidin-1-yl)hexyl]oxy}-3-methyl-2-phenyl-4H-chromen-4-one
Smiles: CC1C(=O)C2=CC(=CC=C2OC=1C1C=CC=CC=1)OCCCCCCN1CCC(O)CC1
InChiKey: RFUIYSLMVBVREF-UHFFFAOYSA-N
InChi: InChI=1S/C27H33NO4/c1-20-26(30)24-19-23(11-12-25(24)32-27(20)21-9-5-4-6-10-21)31-18-8-3-2-7-15-28-16-13-22(29)14-17-28/h4-6,9-12,19,22,29H,2-3,7-8,13-18H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity.
Products are for research use only. Not for human use.
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