GNE-6468


Catalog No. Size PriceQuantity
M21940-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC.

Product information

CAS Number: 1677668-27-7

Molecular Weight: 433.84

Formula: C23H16ClN3O4

Chemical Name: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid

Smiles: OC(=O)C1=CC=C(C=C1O)C1N=C(C(=O)C2C(Cl)=CC=CC=2C2CC2)N2C=CC=NC2=1

InChiKey: GIYKJPISDNWSJD-UHFFFAOYSA-N

InChi: InChI=1S/C23H16ClN3O4/c24-16-4-1-3-14(12-5-6-12)18(16)20(29)22-26-19(21-25-9-2-10-27(21)22)13-7-8-15(23(30)31)17(28)11-13/h1-4,7-12,28H,5-6H2,(H,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (11.52 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CLhep = 17 and 42 mL/min/kg, respectively) .

Products are for research use only. Not for human use.

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