Belizatinib


Catalog No. Size PriceQuantity
M21959-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

Product information

CAS Number: 1357920-84-3

Molecular Weight: 577.73

Formula: C33H44FN5O3

Chemical Name: 4-fluoro-N-(6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[(1s,4s)-4-[(propan-2-yl)carbamoyl]cyclohexyl]-1H-1,3-benzodiazol-2-yl)benzamide

Smiles: CC(C)NC(=O)[C@@H]1CC[C@@H](CC1)N1C(NC(=O)C2C=CC(F)=CC=2)=NC2=CC=C(CN3CCC(CC3)C(C)(C)O)C=C12

InChiKey: WSTUJEXAPHIEIM-FEGDYQJNSA-N

InChi: InChI=1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)/t24-,27+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 300 mg/mL (519.27 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

TSR-011 has antitumour activity in the clinical trials.

In Vivo:

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.

Products are for research use only. Not for human use.

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