Oleoyl Ethyl Amide


Catalog No. Size PriceQuantity
M22039-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity . Fatty acid amide hydrolase (FAAH) is an integral membrane hydrolase and a member of the serine hydrolase family of enzymes. In vitro, FAAH has esterase and amidase activity. In vivo, FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs). Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor. In rat brain homogenates, Oleoyl Ethyl Amide inhibited FAAH activity with IC50 value of 5.25 nM, but did not bind to CB1 or CB2 receptors, or inhibit acidic PEAase. Oleoyl Ethyl Amide is a potent and selective FAAH inhibitor with potential analgesic and anxiolytic activity . In Sprague-Dawley rats, subcutaneous injections of OEtA (0.3 mg/kg) for 2 weeks increased values of micturition intervals (MI) and volumes (MV), bladder capacity (BC), threshold pressure, and flow pressure. OEtA altered sensory urodynamic parameters and reduced bladder overactivity .

Product information

CAS Number: 85075-82-7

Molecular Weight: 309.53

Formula: C20H39NO

Chemical Name: (9Z)-N-ethyloctadec-9-enamide

Smiles: CCCCCCCC/C=C\CCCCCCCC(=O)NCC

InChiKey: JZJYYCFYGXPUMF-QXMHVHEDSA-N

InChi: InChI=1S/C20H39NO/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(22)21-4-2/h11-12H,3-10,13-19H2,1-2H3,(H,21,22)/b12-11-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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