GnRH Associated Peptide (GAP) (1-13), human

Sequence: Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was found to be a potent inhibitor of prolactin secretion and to stimulate the release of gonadotropins. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion. Gonadotropin-releasing hormone (GnRH) is known and named for its essential role in vertebrate reproduction. Release of this decapeptide from neurons in the hypothalamus controls pituitary gonadotropin levels that, in turn, regulate the gonadal state. The importance of GnRH is underscored by its widespread expression and conservation across vertebrate taxa. Also, GnRH-associated peptide (GAP) is co-secreted with GnRH into the hypophyseal portal bloodstream.

Product information

CAS Number: 100111-07-7

Molecular Weight: 1492.58

Formula: C65H101N15O25

Chemical Name: 4-[2-(2-amino-3-carboxypropanamido)propanamido]-4-[(2-carbamoyl-1-{[1-({1-[(1-{[1-({1-[(3-carbamoyl-1-{[3-carboxy-1-({1-[(1-carboxy-2-methylpropyl)carbamoyl]-2-methylbutyl}carbamoyl)propyl]carbamoyl}propyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-2-carboxyethyl)carbamoyl]-2-methylbutyl}carbamoyl)-3-methylbutyl]carbamoyl}ethyl)carbamoyl]butanoic acid

Smiles: CC(C)CC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(N)CC(O)=O)C(=O)NC(C(C)CC)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC1C=CC=CC=1)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC(C(C)C)C(O)=O

InChiKey: SLLIDJFLMJLJIA-UHFFFAOYSA-N

InChi: InChI=1S/C65H101N15O25/c1-10-31(7)51(80-61(100)39(23-29(3)4)73-59(98)41(26-45(68)83)75-56(95)37(18-21-46(84)85)70-53(92)33(9)69-54(93)35(66)25-48(88)89)63(102)76-42(27-49(90)91)60(99)77-43(28-81)62(101)74-40(24-34-15-13-12-14-16-34)58(97)72-36(17-20-44(67)82)55(94)71-38(19-22-47(86)87)57(96)79-52(32(8)11-2)64(103)78-50(30(5)6)65(104)105/h12-16,29-33,35-43,50-52,81H,10-11,17-28,66H2,1-9H3,(H2,67,82)(H2,68,83)(H,69,93)(H,70,92)(H,71,94)(H,72,97)(H,73,98)(H,74,101)(H,75,95)(H,76,102)(H,77,99)(H,78,103)(H,79,96)(H,80,100)(H,84,85)(H,86,87)(H,88,89)(H,90,91)(H,104,105)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.