Description
Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents. Being structurally similar to anther peptide PanxE1B, 10Panx is three amino acid shorter but exerting an inhibitory effect against pannexin1 currents in oocytes to a similar extent as PanxE1b. 10Panx is also able to block the activation of I2nd, decrease the bradykinin-induced [Ca2+]i response and attenuate bradykinin-induced ATP release from human fibroblasts loaded with quinacrine. However, in several studies, scrambled 10Panx has been proved to be less effective than 10Panx in its authentic form.
Product information
CAS Number: 1315378-72-3
Molecular Weight: 1242.34
Formula: C58H79N15O16
Chemical Name: 2-{2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-phenylpropanamido)-3-hydroxypropanamido]-3-methylbutanamido}-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanamido]propanamido}-4-carbamoylbutanamido)propanamido]-3-carboxypropanamido}-5-[(diaminomethylidene)amino]pentanoic acid
Smiles: CC(C)C(NC(=O)C(CO)NC(=O)C(N)CC1=CC=CC=C1)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CC1=CNC2=CC=CC=C12)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC(C)C(=O)NC(CC(O)=O)C(=O)NC(CCCN=C(N)N)C(O)=O
InChiKey: VNQGVHMGXBRHRA-UHFFFAOYSA-N
InChi: InChI=1S/C58H79N15O16/c1-29(2)47(73-55(86)44(28-74)72-50(81)37(59)23-32-11-6-5-7-12-32)56(87)71-41(24-33-16-18-35(75)19-17-33)53(84)70-42(25-34-27-64-38-14-9-8-13-36(34)38)52(83)66-30(3)48(79)67-39(20-21-45(60)76)51(82)65-31(4)49(80)69-43(26-46(77)78)54(85)68-40(57(88)89)15-10-22-63-58(61)62/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,82)(H,66,83)(H,67,79)(H,68,85)(H,69,80)(H,70,84)(H,71,87)(H,72,81)(H,73,86)(H,77,78)(H,88,89)(H4,61,62,63)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.