CD 2314


Catalog No. Size PriceQuantity
M22626-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CD 2314 is a potent and selective agonist of RARβ with Kd value of 145 and >3760 nM for RARβ and RARα receptors, respectively . Retinoic acid receptor β (RARβ) is a nuclear receptor for retinoic acid and localizes to the cytoplasm and subnuclear compartments. RARβ mediates cellular signalling in cell growth, differentiation and embryonic morphogenesis. CD 2314 is a potent and selective RARβ agonist. CD 2314 didn’t inhibit the activation-induced apoptosis of thymocytes because of the absent of RARβ in the thymus . CD 2314 inhibited cells growth with IC50 values of 8.0, 3.0, 5.7 and >10 μM for human head and neck squamous cell carcinoma (HNSCC) 22A, 22B, 183A and 886 cell lines, respectively. In UMSCC22B cells, the combination of CD2314 with RXR-selective retinoids, such as SR11234, SR11203, SR11246 and SR11236 inhibited cells growth . In KG-1 cells, CD 2314 didn’t induce folate receptor β (FR-β) expression, indicating that the induction of FR-β was not mediated by RARβ .

Product information

CAS Number: 170355-37-0

Molecular Weight: 364.50

Formula: C23H24O2S

Chemical Name: 5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydroanthracen-2-yl)thiophene-3-carboxylic acid

Smiles: CC1(C)CCC(C)(C)C2C=C3C=CC(=CC3=CC1=2)C1=CC(=CS1)C(O)=O

InChiKey: URUSABQSUCBGGJ-UHFFFAOYSA-N

InChi: InChI=1S/C23H24O2S/c1-22(2)7-8-23(3,4)19-11-16-9-15(6-5-14(16)10-18(19)22)20-12-17(13-26-20)21(24)25/h5-6,9-13H,7-8H2,1-4H3,(H,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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