Description
AH 23848 (calcium salt) is a dual antagonist of TP1 and EP4 receptors . The thromboxane receptor (TP), also known as the prostanoid TP receptor, is activated by thromboxane A2 (TXA2). TXA2 is an exceptionally potent inducer of platelet aggregation and of contraction of vascular and respiratory smooth muscle . Prostaglandin E2 (PGE2) subtype receptors (EP) are involved in cellular proliferation and tumor development. Prostaglandin E2 (PGE2) activates four EP receptors, EP1-4. The EP4 receptor is coupled to Gs and mediates increases in cAMP concentration by activation of adenylyl cyclase . AH 23848 (calcium salt) is a dual antagonist of TP1 and EP4 receptors. AH 23848 is an orally active, potent and specific thromboxane receptor-blocking drug that has a long duration of action. AH 23848 inhibited TXA2-induced platelet aggregation and antagonized the contraction of human bronchial smooth muscle induced by the TP agonist U-46619 with pA2 of 8.3 . In 3T6 fibroblasts, AH-23848B induced accumulation of cells in early S phase and lowered cyclin A levels . In syngeneic BALB/cByJ female mice injected with line 66.1 or 410.4 tumor cells, AH23848 inhibited the metastasis of line 66.1 and 410.4 cells .
Product information
CAS Number: 81496-19-7
Molecular Weight: 993.25
Formula: C58H68CaN2O10
Chemical Name: calcium bis((4Z)-7-[(1R,2R,5S)-5-({[1,1'-biphenyl]-4-yl}methoxy)-2-(morpholin-4-yl)-3-oxocyclopentyl]hept-4-enoate)
Smiles: [Ca+2].[O-]C(=O)CC/C=C\CC[C@@H]1[C@H](C(=O)C[C@@H]1OCC1C=CC(=CC=1)C1C=CC=CC=1)N1CCOCC1.[O-]C(=O)CC/C=C\CC[C@@H]1[C@H](C(=O)C[C@@H]1OCC1C=CC(=CC=1)C1C=CC=CC=1)N1CCOCC1
InChiKey: JDEBIDDIERGZQY-KFZBTSSDSA-L
InChi: InChI=1S/2C29H35NO5.Ca/c2*31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30;/h2*1-5,8-9,12-15,25,27,29H,6-7,10-11,16-21H2,(H,32,33);/q;;+2/p-2/b2*2-1-;/t2*25-,27-,29+;/m00./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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