Pyrrolidino PAF C-16


Catalog No. Size PriceQuantity
M22750-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16 with hypotensive action . Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF have potent hypotensive activity. C16-PAF was about three times more potent than C18-PAF in the activity of releasing serotonin . Pyrrolidino PAF C-16, a synthetic analog of PAF C-16, is a potent mediator of PAF-like activities, including hypotension and platelet aggregation . In male Wistar rats, Pyrrolidino PAF C-16 dose-dependently decreased blood pressure and the duration of the hypotension was also dose-dependent. Pyrrolidino PAF C-16 was 3-10 times more potent than natural PAF in the hypotensive activity .

Product information

CAS Number: 91021-63-5

Molecular Weight: 549.72

Formula: C28H56NO7P

Chemical Name: 1-(2-{[(2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl phosphonato]oxy}ethyl)-1-methylpyrrolidin-1-ium

Smiles: CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+]1(C)CCCC1)OC(C)=O

InChiKey: QBLLCUIJMABRFJ-MUUNZHRXSA-N

InChi: InChI=1S/C28H56NO7P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-19-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3)20-17-18-21-29/h28H,4-26H2,1-3H3/t28-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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