Description
AZ 12080282 dihydrochloride is a selective inhibitor of Hh with IC50 value <0.012 μM . It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency . Hedgehog (Hh) signaling plays an important role in a wide variety of developmental processes, including larval body segment development and adult appendages formation. Abnormal activation of Hh pathway may lead to developmental disease by transforming adult stem cells into cancer stem cells and also leads to cancers via increasing in Angiogenic Factors, Cyclins, anti-apoptotic genes and decreasing in apoptotic genes . AZ 12080282 is a potent Hh inhibitor and is different from the other reported Hh inhibitors. When tested with Gli transcription factor reporter cell, AZ 12080282 treatment resulted in the Hh signaling pathway inhibition by using shh stimulated cell differentiation assay .
Product information
Molecular Weight: 457.35
Formula: C23H22Cl2N4O2
Chemical Name: N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide dihydrochloride
Smiles: Cl.Cl.CC1C=CC(=CC=1NC(=O)C1C=CC(=CC=1)OCC1C=CC=CN=1)C1NC=CN=1
InChiKey: CPORFOBFIDPDLZ-UHFFFAOYSA-N
InChi: InChI=1S/C23H20N4O2.2ClH/c1-16-5-6-18(22-25-12-13-26-22)14-21(16)27-23(28)17-7-9-20(10-8-17)29-15-19-4-2-3-11-24-19;;/h2-14H,15H2,1H3,(H,25,26)(H,27,28);2*1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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