Adrenomedullin (1-12), human

Adrenomedullin (AM) (1-12), human (C64H100N22O19S1), is a peptide with the sequence Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg . It was first discovered to be associated with pheochromocytoma, a tumor arising from adrenal medulla, in 1993. AM was initially identified as a vasodilator, and as such, it has the ability to relax vascular tone. Previous research cited it as the most potent endogenous vasodilatory peptide found in the body. Other effects of AM include the increase of cell tolerance to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular conditions.

Product information

Molecular Weight: 1513.68

Formula: C64H100N22O19S

Chemical Name: (2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-5-carbamimidamidopentanamido]-4-carbamoylbutanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]-3-carbamoylpropanamido]-3-carbamoylpropanamido]-3-phenylpropanamido]-4-carbamoylbutanamido]acetamido}-4-methylpentanamido]-5-carbamimidamidopentanoic acid

Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChiKey: ZOAAQYOLPIJQIT-HDKAIKTRSA-N

InChi: InChI=1S/C64H100N22O19S/c1-32(2)25-42(57(99)82-41(62(104)105)12-8-23-75-64(72)73)77-51(93)30-76-53(95)38(17-19-47(66)89)79-58(100)43(27-33-9-5-4-6-10-33)83-59(101)45(29-50(69)92)85-60(102)44(28-49(68)91)84-56(98)40(21-24-106-3)81-61(103)46(31-87)86-55(97)39(18-20-48(67)90)80-54(96)37(11-7-22-74-63(70)71)78-52(94)36(65)26-34-13-15-35(88)16-14-34/h4-6,9-10,13-16,32,36-46,87-88H,7-8,11-12,17-31,65H2,1-3H3,(H2,66,89)(H2,67,90)(H2,68,91)(H2,69,92)(H,76,95)(H,77,93)(H,78,94)(H,79,100)(H,80,96)(H,81,103)(H,82,99)(H,83,101)(H,84,98)(H,85,102)(H,86,97)(H,104,105)(H4,70,71,74)(H4,72,73,75)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.