Description
Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | His-Leu) is an octapeptide that is converted from Angiotensin I (AI) through the removal of two C-terminal residues by angiotensin-converting enzyme (ACE), primarily by ACE within the lung (but also those present in endothelial and kidney epithelial cells). Ang-(1–7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively. Angiotensin I/II (1-7) amide is an amide derivative of angiotensin II that is a powerful vasoconstrictor and vasopressor, and is used in the treatment of certain hypotensive states. Angiotensin I/II (1-7) amide is usually administered by slow intravenous infusion, and sometimes intramuscularly or subcutaneously.
Product information
Molecular Weight: 825.96
Formula: C38H59N13O8
Chemical Name: (2R)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[2-(methylamino)acetamido]pentanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxamide
Smiles: CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@@H]1C(N)=O
InChiKey: NALZZXOOGWXZAH-ISWFVRNRSA-N
InChi: InChI=1S/C38H59N13O8/c1-5-21(2)31(36(58)49-28(17-24-18-43-20-45-24)37(59)51-15-7-9-29(51)32(39)54)50-35(57)27(16-23-10-12-25(52)13-11-23)48-33(55)22(3)46-34(56)26(47-30(53)19-42-4)8-6-14-44-38(40)41/h10-13,18,20-22,26-29,31,42,52H,5-9,14-17,19H2,1-4H3,(H2,39,54)(H,43,45)(H,46,56)(H,47,53)(H,48,55)(H,49,58)(H,50,57)(H4,40,41,44)/t21-,22-,26-,27-,28-,29+,31-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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