Description
PSB 1114 is a potent and selective agonist of P2Y2 receptor with EC50 value of 0.134 μM . P2Y2 receptor is a purinergic G protein-coupled receptor and is activated by ATP and UTP. P2Y2 receptor is a potential target for treatment of cystic fibrosis. PSB 1114 is a potent and selective P2Y2 receptor agonist. PSB 1114 activated P2Y2, P2Y4 and P2Y6 with EC50 values of 0.134, 9.3 and 7.0 μM respectively and exhibited >60-fold selectivity versus P2Y6 and P2Y4 receptors .
Product information
CAS Number: 1657025-60-9
Molecular Weight: 622.14
Formula: C10H11F2N2Na4O13P3S
Chemical Name: tetrasodium {[({[(2R,3S,4R)-3,4-dihydroxy-5-(2-oxo-4-sulfanyl-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)(oxido)phosphoryl]difluoromethyl}phosphonate
Smiles: [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)C(F)(F)P([O-])(=O)OP([O-])(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)N1C=CC(S)=NC1=O
InChiKey: KATPYMNMKKBLAH-GENVZAMMSA-J
InChi: InChI=1S/C10H15F2N2O13P3S.4Na/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(15)7(16)8(26-4)14-2-1-5(31)13-9(14)17;;;;/h1-2,4,6-8,15-16H,3H2,(H,21,22)(H,23,24)(H,13,17,31)(H2,18,19,20);;;;/q;4*+1/p-4/t4-,6-,7-,8?;;;;/m1..../s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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