Description
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.
Product information
CAS Number: 2095677-20-4
Molecular Weight: 602.70
Formula: C25H19Br2ClN4O2
Chemical Name: (2S)-1-(4-bromobenzoyl)-4-{6-bromopyrazolo[1,5-a]pyridine-3-carbonyl}-2-(4-chlorophenyl)piperazine
Smiles: O=C(C1C=CC(Br)=CC=1)N1CCN(C[C@@H]1C1C=CC(Cl)=CC=1)C(=O)C1C=NN2C=C(Br)C=CC2=1
InChiKey: WKKAVTNXNVPCCN-HSZRJFAPSA-N
InChi: InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (165.92 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities.
Products are for research use only. Not for human use.
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