eIF4A3-IN-2


Catalog No. Size PriceQuantity
M23480-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

Product information

CAS Number: 2095677-20-4

Molecular Weight: 602.70

Formula: C25H19Br2ClN4O2

Chemical Name: (2S)-1-(4-bromobenzoyl)-4-{6-bromopyrazolo[1,5-a]pyridine-3-carbonyl}-2-(4-chlorophenyl)piperazine

Smiles: O=C(C1C=CC(Br)=CC=1)N1CCN(C[C@@H]1C1C=CC(Cl)=CC=1)C(=O)C1C=NN2C=C(Br)C=CC2=1

InChiKey: WKKAVTNXNVPCCN-HSZRJFAPSA-N

InChi: InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (165.92 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities.

Products are for research use only. Not for human use.

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