RET-IN-1


Catalog No. Size PriceQuantity
M23842-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

Product information

CAS Number: 2222755-14-6

Molecular Weight: 553.61

Formula: C29H31N9O3

Chemical Name: 4-(5-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl}pyrazin-2-yl)-6-{[(2R)-morpholin-2-yl]methoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

Smiles: COC1=CC=C(CN2C3CN(CC2C3)C2=CN=C(C=N2)C2=CC(=CN3N=CC(C#N)=C32)OC[C@H]2CNCCO2)C=N1

InChiKey: GTQISTQEBXXLPC-UBVWURDFSA-N

InChi: InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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