PF-06446846 hydrochloride


Catalog No. Size PriceQuantity
M23937-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34.

Product information

CAS Number: 1632250-50-0

Molecular Weight: 470.35

Formula: C22H21Cl2N7O

Chemical Name: N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-{3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl}benzamide hydrochloride

Smiles: Cl.O=C(C1C=CC(=CC=1)N1N=NC2=CC=CN=C12)N([C@H]1CNCCC1)C1=NC=CC=C1Cl

InChiKey: AQSJYIVIWBIHOU-UNTBIKODSA-N

InChi: InChI=1S/C22H20ClN7O.ClH/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21;/h2-3,5-10,12-13,17,24H,1,4,11,14H2;1H/t17-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (531.52 mM; Need ultrasonic). H2O : 100 mg/mL (212.61 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM.

In Vivo:

PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.

Products are for research use only. Not for human use.

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