Description
Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.
Product information
CAS Number: 960495-43-6
Molecular Weight: 635.51
Formula: C24H25Cl2FN4O7S2
Chemical Name: 3-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]-1-(2-chloro-3-fluorophenyl)urea; 4-methylbenzene-1-sulfonic acid
Smiles: CC1C=CC(=CC=1)S(O)(=O)=O.OC1=C(C(Cl)=CC=C1NC(=O)NC1=CC=CC(F)=C1Cl)S(=O)(=O)N1CCNCC1
InChiKey: CJAUWWGOABMMJX-UHFFFAOYSA-N
InChi: InChI=1S/C17H17Cl2FN4O4S.C7H8O3S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24;1-6-2-4-7(5-3-6)11(8,9)10/h1-5,21,25H,6-9H2,(H2,22,23,26);2-5H,1H3,(H,8,9,10)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (196.69 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion.
Products are for research use only. Not for human use.
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