O-Nornuciferine


Catalog No. Size PriceQuantity
M24045-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor.

Product information

CAS Number: 3153-55-7

Molecular Weight: 281.35

Formula: C18H19NO2

Chemical Name: (9R)-16-methoxy-10-methyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2,4,6,13,15-hexaen-15-ol

Smiles: CN1CCC2=CC(O)=C(OC)C3=C2[C@H]1CC1=CC=CC=C13

InChiKey: AKXOIHNFHOEPHN-CQSZACIVSA-N

InChi: InChI=1S/C18H19NO2/c1-19-8-7-12-10-15(20)18(21-2)17-13-6-4-3-5-11(13)9-14(19)16(12)17/h3-6,10,14,20H,7-9H2,1-2H3/t14-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

O-Nornuciferine has an IC50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids.

Products are for research use only. Not for human use.

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