Chlorahololide C


Catalog No. Size PriceQuantity
M24050-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM.

Product information

CAS Number: 1007859-25-7

Molecular Weight: 576.63

Formula: C33H36O9

Chemical Name: methyl 2-[7-(acetyloxy)-16,21-dihydroxy-5,13,20-trimethyl-9-methylidene-4,22-dioxo-3-oxaoctacyclo[14.7.1.0²,⁶.0²,¹⁴.0⁸,¹³.0¹⁰,¹².0¹⁷,¹⁹.0²⁰,²⁴]tetracosa-1(24),5-dien-23-ylidene]propanoate

Smiles: COC(=O)C(C)=C1C2=C3C(O)(CC4C52OC(=O)C(C)=C5C(OC(C)=O)C2C(=C)C5CC5C24C)C2CC2C3(C)C(O)C1=O

InChiKey: FUWHPWXSVUDXDS-NDENLUEZSA-N

InChi: InChI=1S/C33H36O9/c1-11-15-8-16(15)30(5)19-10-32(39)18-9-17(18)31(6)26(32)23(20(24(35)27(31)36)12(2)28(37)40-7)33(19)22(13(3)29(38)42-33)25(21(11)30)41-14(4)34/h15-19,21,25,27,36,39H,1,8-10H2,2-7H3/b20-12-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Chlorahololide C (0.1-100 μM) inhibits the delayed rectifier K+ current (IK) in rat dissociated hippocampal neurons, with an IC50 of 3.6 μM.

Products are for research use only. Not for human use.

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