Datelliptium chloride hydrochloride

Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors.

Product information

CAS Number: 157000-76-5

Molecular Weight: 434.40

Formula: C23H29Cl2N3O

Chemical Name: 2-[2-(diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium hydrochloride chloride

Smiles: [Cl-].Cl.CC1=C2NC3=CC=C(O)C=C3C2=C(C)C2=C[N+](CCN(CC)CC)=CC=C12

InChiKey: QLZIAISICLKYOX-UHFFFAOYSA-N

InChi: InChI=1S/C23H27N3O.2ClH/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23;;/h7-10,13-14,27H,5-6,11-12H2,1-4H3;2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.

In Vivo:

Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo. Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease. Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210.

Products are for research use only. Not for human use.